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Experimental egg before fertilization
Photo: Mitalipova laboratory
The experimental method was described in the study, Posted in Nature Communications, informs CNN.
To create an egg, scientists have used nuclei from skin cells – they contain a large part of genetic information. Subsequently, they were transplanted into a donor egg that did not have their own nucleus.
Researchers used the method through which scientists cloned in 1997 Dolly’s sheep. However, in the case of new work, its authors created an egg that was a genetic copy of one of the potential parents. It helped to get eggs that had a common DNA with a person whose skin was used.
In total, scientists have created 82 functional oocytes – immature eggs, which were subsequently fertilized in the laboratory.
The biggest call of the researchers was to make sure that the fertilized egg has the right amount of chromosomes.
To do this, they developed a method of removing unnecessary chromosomes that mimic the natural division of cells.
Despite these achievements Less than 9% of eggs survived to a stage that corresponds to the fifth or sixth day after fertilization. In case of Eco At this time, embryos are usually transferred to the uterus.
The scientist Shukhrat Mitalipov noted that even with natural reproduction, only about a third of embryos reach this stage of development.
Besides all embryos created They had chromosomal anomalies. Paul Amato’s study co -author explained that because of that of them can’t be born healthy children Or fruits are likely to stop prematurely.
The authors of the work believe that the method can be a new milestone in developing ways to combat infertility. However, additional research requires that scientists learn better how chromosomes are combined and separated when creating an egg.
“At this stage, this remains only a proof of the concept. Further research is required to ensure efficiency and safety before future clinical applications”– the authors of the work added.
Professor of Reproductive Medicine In Internal Chonga noted that the cloning -related method can face many difficulties before using technology in practice – currently prohibited reproductive human reproductive cloning in many countries.
“Although it is a very early laboratory work, in the future it can change our understanding of infertility and miscarriages. Maybe one day it will open the door to create eggs or sperm for those who do not have other options”– said the scientist who did not participate in the study.
Earlier we told About a startup in the United States, which promises to analyze embryos for thousands of potential diseases of the unborn child.
”, – WRITE: www.pravda.com.ua
Experimental egg before fertilization
Photo: Mitalipova laboratory
The experimental method was described in the study, Posted in Nature Communications, informs CNN.
To create an egg, scientists have used nuclei from skin cells – they contain a large part of genetic information. Subsequently, they were transplanted into a donor egg that did not have their own nucleus.
Researchers used the method through which scientists cloned in 1997 Dolly’s sheep. However, in the case of new work, its authors created an egg that was a genetic copy of one of the potential parents. It helped to get eggs that had a common DNA with a person whose skin was used.
In total, scientists have created 82 functional oocytes – immature eggs, which were subsequently fertilized in the laboratory.
The biggest call of the researchers was to make sure that the fertilized egg has the right amount of chromosomes.
To do this, they developed a method of removing unnecessary chromosomes that mimic the natural division of cells.
Despite these achievements Less than 9% of eggs survived to a stage that corresponds to the fifth or sixth day after fertilization. In case of Eco At this time, embryos are usually transferred to the uterus.
The scientist Shukhrat Mitalipov noted that even with natural reproduction, only about a third of embryos reach this stage of development.
Besides all embryos created They had chromosomal anomalies. Paul Amato’s study co -author explained that because of that of them can’t be born healthy children Or fruits are likely to stop prematurely.
The authors of the work believe that the method can be a new milestone in developing ways to combat infertility. However, additional research requires that scientists learn better how chromosomes are combined and separated when creating an egg.
“At this stage, this remains only a proof of the concept. Further research is required to ensure efficiency and safety before future clinical applications”– the authors of the work added.
Professor of Reproductive Medicine In Internal Chonga noted that the cloning -related method can face many difficulties before using technology in practice – currently prohibited reproductive human reproductive cloning in many countries.
“Although it is a very early laboratory work, in the future it can change our understanding of infertility and miscarriages. Maybe one day it will open the door to create eggs or sperm for those who do not have other options”– said the scientist who did not participate in the study.
Earlier we told About a startup in the United States, which promises to analyze embryos for thousands of potential diseases of the unborn child.